There are cruises from Charleston to the Golden Isles of Georgia. They are on American Cruise Lines. See the details below.
The Golden Isles are a group of four barrier islands on the coast of Georgia. They include St Simons Island, Sea Island, Jekyll Island, and Little St Simons Island.
Sapelo Island has the mansion of RJ Reynolds, a lighthouse, and the University of Georgia Marine Institute.
St Simons Island is the largest of the Golden Isles. Rent bikes to ride around, play golf, or relax on the beach. Historic sites include a working lighthouse, the Bloody Marsh battle site, and Fort Frederica.
Jekyll Island was once a private retreat of the wealthiest families. Historic "cottages" belonged to JP Morgan, Joseph Pulitzer, William Rockefeller, Cornelius Vanderbilt and others. The Georgia Sea Turtle Center is another attraction, along with 20 miles of bike trails and golf courses.
Alternatively, you can go in the other direction on a cruise from Jacksonville to Charleston. Those visit the same ports in the opposite order.